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Polyketides with New Delhi metallo-β-lactamase 1 inhibitory activity from Penicillium sp.
来源: 时间:2014-07-08 浏览次数:3084
Polyketides with NewDelhi metallo-β-lactamase 1inhibitoryactivity from Penicillium sp.
  • Institute of Medicinal Biotechnology, Chinese Academy of Medical Sciences and Peking Union Medical College , Beijing 100050, People's Republic of China.
Abstract
Three new polyketide compounds (1-3), a new quinolone alkaloid (4), and seven known polyketide derivatives were identified from the cultures of Penicillium sp. I09F 484, a strain isolated from the rhizosphere soil of the plant Picea asperata from Kanas Lake, Xinjiang, China. Their structures were elucidated by extensive spectroscopic data analysis. The absolute configurations of 1 and 4 were established by quantum chemical time-dependent density functional theory electronic circular dichroism calculation and Marfey's method, respectively. Compounds 1 and 2 displayed inhibitory activity against New Delhi metallo-β-lactamase 1 with IC?? values of 94.9 and 87.9 μM, respectively.